The article considers the problems of coolant flow computational diagnostics in a closed circulation loop. The mathematical models of acoustic waves in two-phase flow are developed. Indirect diagnostic information, contained in the flow vibrational spectra recorded by regular systems is used. The inverse eigenvalue problem is formulated. Solving it the optimization approach is implemented. It is supposed that partial criteria are presented by continuous, Lipschitz, not everywhere differentiable, multi-extremal functions. Search of global solutions was performed using a new hybrid algorithms integrating stochastic algorithm of variable space viewing and deterministic methods of local search. A numerical example of model diagnosing the phase composition of the coolant in the circulation loop of nuclear reactor plant is presented.
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